Ageless and Outrageous

Podcast by Kristin Jackson

Ageless and Outrageous

Welcome to "Ageless & Outrageous", the podcast where urogynecologist and hormone and sexual health expert, Dr. Kristin Jackson, shares her 25 years of expertise to guide both men and women on the path to aging amazingly. Listen as she dives into a spectrum of topics, with an emphasis on hormone optimization, pelvic floor health, and maintaining vibrant sexual experiences as we age. From exploring the intricacies of hormonal balance to discussing strategies for pelvic floor well-being, Dr. Jackson brings you real-life insights rooted in solid scientific knowledge. Get ready for a podcast that combines the wisdom of years of medical practice with an approach that's relatable and enjoyable. Tune in for a dose of laughter, knowledge, and a rejuvenated perspective on the incredible adventure of growing older.

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Latest episodes

09 July 2025

Estrogen and Alzheimer’s: What 6 Million Women Taught Us

Let’s talk about something most doctors still aren’t saying clearly enough: estrogen matters for your brain. In this episode, I review what the research actually shows about HRT and long-term brain protection.

Alzheimer’s disease is the leading cause of death for women over 65 in the U.S. and Australia. And it’s not just because we live longer — women are more biologically vulnerable. One major reason? Estrogen loss.

Let's look at a 2023 comprehensive review of over 6 million women that looked at whether hormone therapy helps or harms brain health. Spoiler alert: timing matters. This episode is especially important for women in perimenopause or newly postmenopausal who are being told to “just wait it out.”

The Alzheimer’s crisis in women
- Over 2/3 of Alzheimer’s cases are women
- Not just about longevity — estrogen plays a direct role in brain protection
Major takeaways from the 2023 neuroscience meta-analysis
- Over 6 million women studied
- Combined randomized trials + real-world data
- Main finding: Timing and type of hormone therapy make all the difference
When hormone therapy helps protect your brain
- Estrogen started in midlife (around age 50) reduced Alzheimer’s risk by 32%
- Observational studies showed a 22% lower risk of Alzheimer’s and a 19% reduced risk of all-cause dementia
- Women on estrogen-only therapy had better cognitive outcomes than those on estrogen + synthetic progestins
- Longer duration (>6 years) of HRT use = greater brain benefit
When it may not help — or may even increase risk
- Women who start hormone therapy after age 65 or well past menopause may see no benefit or increased risk
- This risk mostly applies to oral estrogen and progestins (synthetic, not bioidentical)
- Think of it like sunscreen: starting after the damage has been done doesn’t help much
The “Window of Opportunity” Concept
- Best brain benefits come from starting HRT during perimenopause or early postmenopause (within 10 years of last period)
- Estrogen is neuroprotective during this transition — but less effective if cognitive decline has already started
Why synthetic progestins fall short
- Studies consistently show better brain outcomes without progestins
- We still lack data on bioidentical progesterone and brain health — more research needed
- Bottom line: avoid synthetic versions if possible
If you’re already over 65 — is it too late?
- Not necessarily
- HRT may still help with other issues like bone, sleep, or quality of life
- But brain protection may not be as significant
- Requires individualized risk-benefit analysis

Every woman deserves a personalized, balanced discussion about hormone therapy — not one-size-fits-all advice based on outdated studies. If you’re in your 40s or 50s, this is the time to have that conversation — not after problems start.

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Website https://www.foundationsfl.com/

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11:51

03 July 2025

Still Flashing at 65? You’re Not Too Late for HRT

In this episode I break down one of the most frustrating myths I hear in women’s health: that once you reach a certain age — usually 60 or 65 — you’re “too old” to start hormone therapy.

Spoiler alert: that is not true. And it’s long overdue that we challenge the outdated thinking behind it.

I walk you through how this myth started, what the science actually shows, and how a personalized, risk-based approach is what really matters — not your birthday.

Key Topics I Cover:

Where the “Too Old” Myth Started: The 2002 WHI study caused panic, but it was never designed to assess quality of life — and its flawed conclusions about age cutoffs still haunt modern care.
The Real Impact of Stopping HRT After 60: Many women were forced off therapy overnight, leading to a resurgence of symptoms and long-term confusion among providers.
The Truth About Vasomotor Symptoms (Hot Flashes & Night Sweats):
- Can last 7–14 years or more
- Up to 1 in 3 women over 65 still suffer from them
- More severe and long-lasting in African American and Hispanic women
Other Menopausal Syndromes That Persist or Worsen With Age:
- Genitourinary Syndrome of Menopause (GSM): Dryness, pain with sex, urinary symptoms
- Musculoskeletal Symptoms: Joint pain, frozen shoulder, hand stiffness
- Sleep Disruption: Even without night sweats, quality of sleep drops significantly
- Cognitive Decline: Brain fog, word-finding issues, memory trouble — not just “getting older”
Why There’s No Magical Cutoff at Age 60 or 65: Menopause isn’t a finish line — it’s a transition. And most women spend 30–40 years post-menopause. We can’t ignore their needs for half their lives.
What New Data Actually Shows:
- Later follow-ups (13+ years) from WHI show no increased risk of heart disease or death in women 60+ on HRT
- Slight increases in stroke and clot risk only apply to oral estrogen — not safer, modern non-oral methods
- Estrogen-alone therapy may reduce risk of dementia-related death
- Cognitive data still evolving — but timing, route, and type of hormone matter
Why a Personalized Risk-Benefit Approach Is Critical: Your chronological age isn’t enough. I look at:
- Bone density
- Heart and brain health
- Sleep quality
- Symptom burden
- Family history
Final Takeaway: If you're being told you can't continue or start hormones because of your age — challenge it. Ask why. And if your provider can’t answer, find one who can.

Instagram https://www.instagram.com/foundationskristinjacksonmd/

Website https://www.foundationsfl.com/

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30:42

19 June 2025

The Forgotten Hormone: Why DHEA Might Be Your Missing Piece

DHEA is one of the most overlooked hormones in the conversation around aging well, but it plays a powerful role in energy, mood, metabolism, and muscle maintenance. I often see patients who are doing everything right—eating clean, sleeping well, on hormone replacement—but still feel like something is missing. That something could be DHEA.

This hormone starts declining in your 30s and 40s, and without it, your body may struggle to produce testosterone, estrogen, and critical immune and brain chemicals. In this episode, I explain how DHEA works, how to know if you’re low, and how to safely supplement it if needed.

Do you want to understand:

What DHEA is and how it differs from other sex hormones
Why DHEA levels start declining as early as your 30s
Symptoms of low DHEA: fatigue, belly fat, low libido, poor muscle tone
How DHEA supports bone growth, immune health, metabolism, and mood
The connection between DHEA and cortisol (stress hormone)
Best practices for testing and ideal blood level targets
Over-the-counter vs. compounded supplements: what to watch out for
DHEA’s use in vaginal health (including Intrarosa and compounded options)
Common misconceptions about hair loss and DHEA
When to consider DHEA as part of a broader HRT strategy

DHEA may not get the attention that estrogen and testosterone do, but it’s a foundational hormone that supports multiple systems in the body. From energy and fat metabolism to mood and immune defense, low DHEA can quietly affect how you feel, look, and function. Supplementing—when guided by lab testing and clinical signs—can help fill in the hormonal gaps and bring new vitality to your day-to-day life. With the right dose and delivery method, it might just be the missing link in your longevity and wellness plan.

Instagram https://www.instagram.com/foundationskristinjacksonmd/

Website https://www.foundationsfl.com/

FB facebook.com/advancedurogynecology

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15:52

12 June 2025

Estrogen Is Everywhere: What They Didn’t Tell You About Menopause

Most people associate estrogen loss with hot flashes and night sweats, but the truth is—estrogen affects nearly every part of the body. I often see women struggling with fatigue, brain fog, bladder irritation, joint pain, and sleep problems, and they’ve never been told these symptoms could be related to perimenopause or menopause. In this episode, I walk through the science of how estrogen functions in different tissues and share real examples from three patients in their 40s, 50s, and 70s—all experiencing very different symptoms tied to the same hormonal shift.

We have to move beyond the idea that menopause only affects the ovaries. When estrogen drops, the brain, bones, muscles, skin, and bladder all feel it—and understanding this opens the door to smarter, more personalized treatment.

You NEED to know:

Why estrogen loss doesn’t always present as hot flashes
The musculoskeletal syndrome of menopause: how estrogen protects joints and muscle
How low estrogen disrupts sleep, mood, memory, and concentration
The role of estrogen in preserving bone mass and preventing fractures
Genitourinary syndrome of menopause (GSM): what happens to the vagina and bladder
Why women can still have low estrogen symptoms even with regular periods
Limitations of hormone blood tests in your 40s
How I approach estrogen therapy in women in their 40s, 50s, and 70s
What vaginal estrogen does (and why it doesn’t increase cancer risk)
Why estrogen is essential—not optional—for aging well

Estrogen does so much more than regulate the menstrual cycle—it influences everything from our joints to our mood to our ability to sleep soundly at night. Understanding how deeply this hormone impacts the entire body is the first step toward reclaiming wellness during perimenopause, menopause, and beyond. Whether symptoms show up subtly or dramatically, they deserve to be taken seriously. With the right evaluation and a personalized treatment plan, it's possible to feel strong, clear, and supported again—at any age.

Read Dr J's blog to find out why personalized hormone replacement is best: https://www.foundationsfl.com/post/precise-personalized-menopausal-hormone-therapy

And you can learn more about all thing hormone replacement here: https://www.foundationsfl.com/bioidentical-hormone-optimization

Instagram https://www.instagram.com/foundationskristinjacksonmd/

Website https://www.foundationsfl.com/

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26:46

05 June 2025

Sermorelin: The Secret to Muscle, Sleep, and Longevity?

In this episode of Ageless and Outrageous, I dive into one of my favorite add-ons for optimizing weight loss, improving recovery, and aging better: Sermorelin. While often confused with growth hormone itself, Sermorelin works upstream—by signaling your pituitary to produce more of your own natural growth hormone. It’s one of the most exciting ways to maintain muscle, reduce visceral fat, and support vibrant aging without shutting down your hormone system.

If you’re doing everything right—strength training, eating protein, balancing your hormones—but still feel like something’s missing, Sermorelin might be the next step.

🔍 Listen in to learn:

What Sermorelin is and how it differs from synthetic growth hormone
How Sermorelin supports muscle growth, bone health, and visceral fat reduction
Why growth hormone production naturally declines with age
Benefits beyond body composition: improved sleep, mood, skin elasticity, and immune function
Why Sermorelin is a safer alternative to direct growth hormone therapy
Proper dosing protocols and why it mimics the body’s natural rhythm
Important precautions: cancer screenings, thyroid health, and IGF-1 monitoring
How Sermorelin can complement your weight loss or HRT program for stronger results

Whether you're working to lose weight, maintain muscle, improve your sleep, or simply feel more vibrant as you age, Sermorelin offers a powerful, science-backed tool to support your goals. It’s not a magic bullet, but when paired with resistance training, optimal protein intake, and balanced hormones, it can take your results to the next level. As always, it’s important to work with a qualified provider to ensure safe and effective use. If you’ve been looking for a way to rebuild from the inside out—Sermorelin might just be the boost your body has been waiting for.

Read Dr J's blog on Sermorelin injections here: https://www.foundationsfl.com/post/sermorelin-could-be-your-secret-weight-loss-weapon

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Website https://www.foundationsfl.com/

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16:50

27 May 2025

Testosterone & Mood: What the Research Really Shows

Let's review a powerful new study on how testosterone therapy can improve mood, cognition, and libido in perimenopausal and menopausal women—even those already on hormone replacement therapy. If you've been struggling with brain fog, irritability, or a loss of motivation and joy, this episode offers a science-backed look at one often-overlooked solution.

Here’s what you’ll discover:

🧪 The results of a large study tracking 510 women who added testosterone to their HRT
🔄 Why common mood and cognitive symptoms may not be “just stress” or “just aging”
💥 A 47% improvement in mood and 52% boost in libido after only four months
🧠 The surprising link between testosterone and brain function in women
🚫 Why the “testosterone is only for men” myth needs to go
🧾 What it means when a treatment is off-label—and why that’s more common than you think
🩺 How I uses testosterone in her practice and what to consider if your current regimen isn’t working
💬 Tools to better describe and track your symptoms, so you can advocate for yourself confidently

Whether you’re already on hormone therapy or just starting to explore options, this episode offers a fresh, practical perspective on what testosterone could do for your quality of life. If you’ve been feeling unlike yourself lately—this conversation might be the missing piece.

Learn more about bioidentical hormone replacement here:

https://www.foundationsfl.com/testosterone-pellet-therapy-orlando

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Website https://www.foundationsfl.com/

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20:37